The letters of the Booth family of Twemlow consist of two series of letters from different generations of the family: the first contains letters from William Booth (b. 1602) to his brother, John Booth (1584-1659), and the second comprises letters of Thomas Booth (b. 1646) to his brother, another John Booth (1641-1698). In both sets of correspondence, the letters are from younger brothers living away from the family estate in Cheshire (from London, the Netherlands, and France) to elder brothers living at Twemlow and include a mixture of family news, financial business, and accounts of contemporary events.

Series 1 (F.c.6-16): All but one of the letters from William Booth are dated 1628-1629, consisting first of letters from London, where he unsuccessfully seeks service and frequently asks for financial assistance (F.c.6-12), and then from the Netherlands, where he is a soldier (F.c.13-15). The letters from the Netherlands offer contemporary accounts of English military actions against Spanish forces. In one much later letter (F.c.16), written from Calais in 1647, William refers to his continued military activity and ongoing request of financial assistance. John Booth's draft replies appear on several of the letters (F.c.7, F.c.9, and F.c.16), as well as a copy of a letter from William Morton to Thomas Morton, then bishop of Lichfield (F.c.6).

Series 2 (F.c.17-34): The letters from Thomas Booth, all sent from London "by the Brereton Bagg" (the post bag bound for Brereton in Cheshire), include a mixture of family and business matters with news of the political situation. Thomas writes to his brother concerning his nephew John's development, commenting on prices of goods, and relating the latest political turmoil of the 1680s.